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Proceedings of the National Academy of Sciences, 2002      The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium
Jonathan A. Eisen, Karen E. Nelson, Ian T. Paulsen, John F. Heidelberg, Martin Wu, Robert J. Dodson, Robert Deboy, Michelle L. Gwinn, William C. Nelson, Daniel H. Haft, Erin K. Hickey, Jeremy D. Peterson, A. Scott Durkin, James L. Kolonay, Fan Yang, Ingeborg Holt, Lowell A. Umayam, Tanya Mason, Michael Brenner, Terrance P. Shea, Debbie Parksey, William C. Nierman, Tamara V. Feldblyum, Cheryl L. Hansen, M. Brook Craven, Diana Radune, Jessica Vamathevan, Hoda Khouri, Owen White, Tanja M. Gruber, Karen A. Ketchum, J. Craig Venter, Hervé Tettelin, Donald A. Bryant, and Claire M. Fraser
Proceedings of the National Academy of Sciences, 2002

The complete genome of the green-sulfur eubacterium Chlorobium tepidum TLS was determined to be a single circular chromosome of 2,154,946 bp. This represents the first genome sequence from the phylum Chlorobia, whose members perform anoxygenic photosynthesis by the reductive tricarboxylic acid cycle. Genome comparisons have identified genes in C. tepidum that are highly conserved among photosynthetic species. Many of these have no assigned function and may play novel roles in photosynthesis or photobiology. Phylogenomic analysis reveals likely duplications of genes involved in biosynthetic pathways for photosynthesis and the metabolism of sulfur and nitrogen as well as strong similarities between metabolic processes in C. tepidum and many Archaeal species.

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