Origins of DNA replication in the three domains of life

Nicholas P. Robinson and Stephen D. Bell
FEBS Journal, 2005 272:3757-3766

Abstract:
Replication of DNA is essential for the propagation of life. It is somewhat surprising then that, despite the vital nature of this process, cellular organisms show a great deal of variety in the mechanisms that they employ to ensure appropriate genome duplication. This diversity is manifested along classical evolutionary lines, with distinct combinations of replicon architecture and replication proteins being found in the three domains of life: the Bacteria, the Eukarya and the Archaea. Furthermore, although there are mechanistic parallels, even within a given domain of life, the way origins of replication are defined shows remarkable variation. (Cdc6; DnaA; DNA Replication; MCM; ORC)

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